The St. Regis Florence, a 15th-century palazzo set along the banks of the Arno River, has inspired the likes of E.M. Forster and Henry James. You’ll be writing tributes to its modern take on Renaissance-era elegance, canopied beds, colorful brocades, custom frescoes and crystal chandeliers. (Book a river-view room facing the Ponte Vecchio, the oldest of Florence’s bridges — very romantic!) The hotel’s service, including personal butlers and the city’s most savvy concierges, is legendary. Multiple Michelin-stars-awarded Chef Valeria Piccini’s vision elevates Tuscan gastronomic culture to the highest degree at Winter Garden by Caino.