Palazzo Seneca in Umbria is much more than a hotel stay. You’ll be cosseted in a 16th-century palace that has been under the loving care of the Bianconi family since 1850 and was named Best of the Best Hotel of the Year in 2017. Restored by local artisans, this stately home welcomes you with 24 individually appointed rooms; farm-to-table cuisine utilizes fresh herbs from the garden and pecorino cheese aged in the cellar. Peruse ancient texts in the library or play tennis; with activities ranging from Umbrian cooking classes to visiting restaurant suppliers to horseback riding and truffle hunting, you’ll never lack things to do.